Vyepti is a monoclonal antibody that is specifically designed for recognition of and a high attraction to calcitonin gene related peptide (CGRP) and prevent migraines.
Trigeminal neurons are the unique anatomical foundation for peripheral initiation of migraines and its central signaling. Trigeminal afferents become more provoked by the release of CGRP initiating a domino effect leading to a migraine.
Vyepti targets and forms a stable binding complex with CGRP and effectively disables the portion of CGRP that activates the CGRP receptor stopping activation of downstream biological activity to prevent migraines.